Approximately 80 scientists are in residence at ICSI, including principal investigators, postdoctoral Fellows, visiting researchers, and students. Since its inauguration in 1988, ICSI has maintained an affiliation with the University of California at Berkeley. Several of ICSI's scientists hold joint faculty appointments at UC Berkeley, teaching graduate and undergraduate courses and supervising students who pursue their doctoral thesis research at ICSI. In addition, ICSI has collaborative ties with external fellows and faculty associates at UC Berkeley and other institutions around the world.

Administrative staff provide computational and research support services, as well as visa and housing assistance for international visitors.